Si-DMA Far Red Probe (1mg)

Si-DMA Far Red Probe (1mg)

Stock Code: 3572556
Manufacturer Part No: SCT063
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£500.04 (exc VAT) per EACH
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Application


Research Sub CategoryLive Cell Dye


Live cell fluorescent imaging


Live cell imaging dye for singlet oxygen (1O2) localized to mitochondria. Singlet oxygen is important in the field of cancer therapy, photodynamic medicine and other skin treatments.


Research CategoryCell Imaging


Disclaimer


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


General description


Singlet oxygen (1O2) is one of the reactive oxygen species (ROS). Singlet oxygen is known to be a cause of spots and wrinkles of the skin due to its very strong oxidizing potential. However, the reactivity of singlet oxygen, if controlled, can be used for therapy. In the field of cancer research and therapy, singlet oxygen is being used for photodynamic therapy (PDT), an emerging anticancer treatment using photoirradiation and photosensitizers.BioTracker﹤TMSYMBOL>﹤/TMSYMBOL> Si-DMA Singlet Oxygen Live Cell Dye is a novel far-red fluorescence probe that is composed of silicon-containing rhodamine and anthracene moieties as a chromophore and a singlet oxygen reactive site, respectively. In the presence of singlet oxygen, fluorescence of BioTracker Si-DMA live cell dye increases 17 times due to endoperoxide formation at the anthracene moiety. The dye is highly selective to singlet oxygen, among seven different reactive oxygen species (1O2, O2-, H2O2, HOCL-, RCO-, OH-, NO). Among three different intracellular photosensitizers, BioTracker Si-DMA selectively detects the 1O2 that is generated by 5-aminolevulinic acid-derived protoporphyrin IX, localized in mitochondria. On the other hand, mitochondria-targeted KillerRed and lysosomal porphyrins could not induce fluorescence change in the dye.Spectral PropertiesAbsorbance: 640 nmEmission: 670 nm


Other Notes


Concentration: Please refer to lot specific datasheet.


Physical form


Lyophilized


Quality


Purity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 513.77 g/mol


Storage and Stability


Store BioTracker Si-DMA Singlet Oxygen Live Cell Dye at 0-5°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.

ManufacturerSIGMA-ALDRICH
Technique(s)cell based assay: suitable
Assay≥98% (elemental analysis), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (H-NMR)

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