QUMA-1 RNA G-quadruplex Dye (1mg)

QUMA-1 RNA G-quadruplex Dye (1mg)

Stock Code: 3572550
Manufacturer Part No: SCT056
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£500.04 (exc VAT) per EACH
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Application


Research Sub CategoryLive Cell Dye


Research CategoryCell ImagingmicroRNARNA Metabolism & Binding Proteins


A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.


Live cell fluorescent imaging


Disclaimer


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


General description


RNA G-quadruplexes are formed by self-assembly of guanine-rich RNA stacks into stacked G-quartets. This can occur in protein-coding (mRNA) as well as non-coding (ncRNA) transcripts. There is growing evidence that RNA G-quadruplexes are involved in different biological functions: telomere elongation, DNA recombination, transcription, RNA post-transcriptional mechanisms (pre-mRNA processing, mRNA turnover, targeting and translation), and are associated with sevral human diseases.BioTracker﹤TMSYMBOL>﹤/TMSYMBOL> QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.Spectral PropertiesAbsorbance: 555 nmEmission: 660 nm


Other Notes


Concentration: Please refer to lot specific datasheet.


Physical form


Lyophilized


Quality


Purity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 628.17 g/mol


Storage and Stability


Store BioTracker QUMA-1 RNA G-quadruplex -Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.

ManufacturerSIGMA-ALDRICH
Technique(s)cell based assay: suitable
Assay≥98% (elemental analysis), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (H-NMR)

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