Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.
6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.
Caution
Hygroscopic; photosensitive
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.), H2O: 3 mg/mL (Dissolve in oxygen-free boiled water containing 0