6-Hydroxy-DL-DOPA, >=98% (TLC), powder

Stock Code: 3591414
Manufacturer Part No: H2380-100MG
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Biochem/physiol Actions

Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.

6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.

Caution

Hygroscopic; photosensitive

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Colouroff-white
Quality Level200
InChI keyYLKRUSPZOTYMAT-UHFFFAOYSA-N
InChI1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
ManufacturerSIGMA-ALDRICH
Solubility1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.), H2O: 3 mg/mL (Dissolve in oxygen-free boiled water containing 0
Formpowder
Assay≥98% (HPLC)

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