6-Aminocaproic acid, >=99% (titration), powder

Stock Code: 3577603
Manufacturer Part No: A2504-5KG

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Descriptions

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl₂, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator.

Packaging

5 kg in poly drum

25, 100, 500 g in poly bottle

1 kg in poly bottle

Specifications

Colour	white
mp	207-209 °C (dec.) (lit.)
InChI key	SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChI	1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥99% (titration)