4(MU)8C

4(MU)8C

Stock Code: 3574284
Manufacturer Part No: SML0949-5MG
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£162.96 (exc VAT) per 5MG
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Biochem/physiol Actions


4µ8C is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. 4µ8C inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of XBP1 mRNA in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.


4?8C is a salicylaldehyde derivative and its inhibitory action targets the K907 lysine residue in RNase (ribonuclease) domain and affects IRE1? (endoplasmic reticulum to nucleus signaling 1) RNase activity. In vitro analysis proved that 4?8C was able to inhibit the release of insulin at high glucose levels.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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