3BDO

3BDO

Stock Code: 3575268
Manufacturer Part No: SML1687-25MG
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£530.68 (exc VAT) per 25MG
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Application


3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.


Biochem/physiol Actions


An orally bioavailable, brain-permeant suppressor of mTOR-mediated autophagy; reduces A? levels and prevents cognitive deficits in A?PP/PS1 mouse model.3-benzyl-5-[(2-nitrophenoxy) methyl]-dihydrofuran-2 (3H)-one (3BDO) blocks rise in LC3-II stimulated by uric acid (UA). It protects the capability of Rheb1-deficient macrophages to perform phagocytosis. 3BDO also prevents the inhibitory effects of EX-527 on eukaryotic translation initiation factor-binding protein 1(4E-BP1) phosphorylation.


3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/-?mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.

Colourcolorless to light brown
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formoil
Assay≥98% (HPLC)

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