1(S),9-(-)-Bicuculline methiodide, >=95.0% (HPCE)

1(S),9-(-)-Bicuculline methiodide, >=95.0% (HPCE)

Stock Code: 3573212
Manufacturer Part No: 14343-10MG
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Application


1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).


Biochem/physiol Actions


(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.


Features and Benefits


This compound is featured on the GABAA Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


General description


Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesteraseinhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).


Preparation Note


prepared from (+)-bicuculline

Quality Level100
InChI keyHKJKCPKPSSVUHY-GRTNUQQKSA-M
InChI1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 10 mg/mL, almost clear, greenish-yellow
Formpowder
Assay≥95.0% (HPCE)

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