(+/-)-Bay K8644, calcium channel agonist

(+/-)-Bay K8644, calcium channel agonist

Stock Code: 3577637
Manufacturer Part No: B112-25MG
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Application


(±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.


Biochem/physiol Actions


(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it?s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.


Increases influx of Ca2+ specifically at voltage-gated calcium channels.


Packaging


5, 25 mg in glass bottle

Colouryellow to dark yellow
Quality Level100
mp168-170 °C
InChI keyZFLWDHHVRRZMEI-UHFFFAOYSA-N
InChI1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥97.5% (HPLC)

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