(+)-Bicuculline, >=97.0% (TLC)

(+)-Bicuculline, >=97.0% (TLC)

Stock Code: 3573209
Manufacturer Part No: 14340-100MG
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Application


Bicuculline has been used: as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiolto study the effects of chronic caffeine administration on the function of GABAA receptorto isolate N-methyl-D-aspartate receptor (NMDAR)-specific evoked and miniature excitatory postsynaptic currents (eEPSCs and mEPSCs) in neurons of rats


Biochem/physiol Actions


(+)-Bicuculline is a GABAA receptor antagonist.


(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.


Features and Benefits


This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


General description


Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

Quality Level100
mp193-197 °C
InChI keyIYGYMKDQCDOMRE-ZWKOTPCHSA-N
InChI1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥97.0% (TLC)

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