MONOCLONAL MESOTHELIN (EP140)

Stock Code: 3573060
Manufacturer Part No: 439R-14

Order Now for 7 day delivery

Descriptions

General description

Mesothelin is a 40 kDa glycosyl-phosphatudylinositol-anchored glycoprotein cleaved from a 71kDa precursor protein encoded by the human mesothelin gene. Mesothelin is present on the surface of normal mesothelial cells.¹ Although the function of mesothelin is unknown, it is overexpressed in a wide variety of cancers including mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.^1-6 Mesothelin has proven to be a valuable marker for pancreatic ductal adenocarcinoma due to its strong reactivity in tumor tissue and absence in normal pancreas.^{1, 3-4} Metastatic renal cell carcinoma can present clinical patterns that mimic primary mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.^{2, 4-6} Mesothelin has demonstrated utility in the differential diagnosis between these primary tumors and corresponding metastatic renal cell carcinoma within the context of an antibody panel.^4-6?

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Mesothelin Positive Control Slides, Product No. 439S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Quality

IVD

RUO

Specifications

Quality Level	100; 500
Manufacturer	SIGMA-ALDRICH
Further Info	(For In Vitro Diagnostic Use in Select Regions (See Chart))
Storage Temp.	2-8°C
Form	buffered aqueous solution