MONOCLONAL TSH (EP254)

MONOCLONAL TSH (EP254)

Stock Code: 3572865
Manufacturer Part No: 211R-16
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General description


Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulate the endocrine function of the thyroid gland. TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit, which are non-covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones: Follicle stimulating hormone and luteinizing hormone and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity. Anti-TSH reacts with TSH-producing cells (thyrotrophs), and is a useful marker in classification of pituitary tumors and the differential identification of primary and metastatic tumors in the pituitary gland.1-5


Legal Information


Cell Marque is a trademark of Sigma-Aldrich Co. LLC


Linkage


TSH Positive Control Slides, Product No. 211S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).


Other Notes


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Physical form


Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.


Preparation Note


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Quality


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Quality Level100; 500
ManufacturerSIGMA-ALDRICH
Further Info(For In Vitro Diagnostic Use in Select Regions (See Chart))
Storage Temp.2-8°C
Formbuffered aqueous solution

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