MONOCLONAL CARBONIC ANHYDRASE IX (CA IX)

MONOCLONAL CARBONIC ANHYDRASE IX (CA IX)

Stock Code: 3573038
Manufacturer Part No: 379R-17
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General description


Carbonic anhydrases are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO﹤sub>2﹤/sub>. Among these, carbonic anhydrase IX (CA IX) is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder1. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme.1-4 CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors.5?Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) with demonstrated sensitivity of 85% to 100%.2 Anti-CA IX, together with antibodies against PAX-2, Ksp-cadherin, and CD117, contributes to a robust panel that can be used to help make this distinction. Strong diffuse-to-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC.6


Legal Information


Cell Marque is a trademark of Sigma-Aldrich Co. LLC


Linkage


Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).


Other Notes


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Physical form


Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.


Preparation Note


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Quality


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Quality Level100; 500
ManufacturerSIGMA-ALDRICH
Further Info(For In Vitro Diagnostic Use in Select Regions (See Chart))
Storage Temp.2-8°C
Formbuffered aqueous solution

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