MONOCLONAL GH (EP267)

MONOCLONAL GH (EP267)

Stock Code: 3572857
Manufacturer Part No: 208R-17
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General description


Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).1-3 It reacts with GH-producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and various benign and malignant cutaneous lesions.4-6


Legal Information


Cell Marque is a trademark of Sigma-Aldrich Co. LLC


Linkage


GH Positive Control Slides, Product No. 208S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).


Other Notes


For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com


Physical form


Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.


Preparation Note


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Quality


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Quality Level100; 500
ManufacturerSIGMA-ALDRICH
Further Info(For In Vitro Diagnostic Use in Select Regions (See Chart))
Storage Temp.2-8°C
Formbuffered aqueous solution

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