ZIBOTENTAN

ZIBOTENTAN

Biochem/physiol Actions

Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.

Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.

General description

Zibotentan is an orally bioavailable, non-peptide ETA (endothelin) receptor-specific antagonist, with no activity against ETB receptor.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3575070 ZIBOTENTAN white to beige 100 FJHHZXWJVIEFGJ-UHFFFAOYSA-N 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25) SIGMA-ALDRICH powder ≥98% (HPLC)
£502.82 (exc VAT) per 25MG
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3575071 ZIBOTENTAN white to beige 100 FJHHZXWJVIEFGJ-UHFFFAOYSA-N 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25) SIGMA-ALDRICH powder ≥98% (HPLC)
£140.68 (exc VAT) per 5MG
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