X-34

X-34

Biochem/physiol Actions

X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.

Fluorescent, amyloid-specific dye

X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule ?-secretase modulators (GSMs) involved in lowering A?42 levels (the 42-residue isoform of the amyloid-? peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer?s disease (AD).

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575611 X-34 white to beige 100 SIGMA-ALDRICH 2-8°C
£605.89 (exc VAT) per 25MG
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3575612 X-34 white to beige 100 SIGMA-ALDRICH 2-8°C
£150.43 (exc VAT) per 5MG
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