VU0155069

VU0155069

Biochem/physiol Actions

VU0155069 is a PLD1-selective catalytic site-targeting phospholipase D inhibitor (PLD1/2 IC50 = 46 nM/933 nM by cell-free enzymatic assays; substrate = di-palmitoyl-PLC) that selectively suppresses the cellular PLD activity in PMA-stimulated non-small-cell lung cancer (NSCLC) Calu-1 cells with predominant PLD1 activity over GFP-PLD2-overexpressing HEK293 cells (IC50 = 11 nM and 1.8 µM, respectively). Note: VU0155069 is reported to impair P2X7-induced pore formation in human RPMI 8226 B cells lacking PLD1 expression.

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Code Description Colour Manufacturer Storage Temp. Form Assay Price Quantity
3576079 VU0155069 white to beige SIGMA-ALDRICH 2-8°C powder ≥98% (HPLC)
£360.05 (exc VAT) per 25MG
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3576080 VU0155069 white to beige SIGMA-ALDRICH 2-8°C powder ≥98% (HPLC)
£89.14 (exc VAT) per 5MG
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