VU0071063

VU0071063

Biochem/physiol Actions

VU0071063 is also known as [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. It serves as a major compound for examining?-cell physiology, KATPchannel gating and a new chemical scaffold for evolving enhanced activators with medicinal chemistry.

VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC50 = 10.3 µM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574520 VU0071063 white to beige 100 ZFZAIHKQJBMYLO-UHFFFAOYSA-N 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
£566.89 (exc VAT) per 25MG
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3574521 VU0071063 white to beige 100 ZFZAIHKQJBMYLO-UHFFFAOYSA-N 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
£136.50 (exc VAT) per 5MG
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