Urotensin II human, >=97% (HPLC), synthetic

Urotensin II human, >=97% (HPLC), synthetic

Amino Acid Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val [Disulfide Bridge: 5-10]

Application

Urotensin II human was used in agonist and antagonist preparation for calcium mobilization assay. The product can also be used as a test compound for studying the impact of dihydropyridine calcium antagonist amlodipine in human internal mammary artery and clinical implications.

Biochem/physiol Actions

Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14.

A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia.

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

0.5, 1 mg in poly bottle

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Code Description Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3593826 Urotensin II human, >=97% (HPLC), synthetic 200 HFNHAPQMXICKCF-USJMABIRSA-N 1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80 SIGMA-ALDRICH
£306.43 (exc VAT) per EACH
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3593827 Urotensin II human, >=97% (HPLC), synthetic 200 HFNHAPQMXICKCF-USJMABIRSA-N 1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80 SIGMA-ALDRICH
£394.18 (exc VAT) per 1MG
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+