Urocortin rat, >=97% (HPLC), powder

Urocortin rat, >=97% (HPLC), powder

Amino Acid Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Application

Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice.

Biochem/physiol Actions

Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1?, 2? and 2?. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

Other Notes

Lyophilized from 0.1% TFA in H2O

Preparation Note

Urocortin rat dissolves in 1% acetic acid at 1 mg/ml to yield a clear, colorless solution.

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Quality Level Manufacturer Technique(s) Storage Temp. Solubility Form Assay Price Quantity
3593824 Urocortin rat, >=97% (HPLC), powder 200 SIGMA-ALDRICH western blot: suitable −20°C
£720.19 (exc VAT) per EACH
-
+
3593825 Urocortin rat, >=97% (HPLC), powder 200 SIGMA-ALDRICH western blot: suitable −20°C
£705.84 (exc VAT) per 1MG
-
+