UPCDC30245

UPCDC30245

Biochem/physiol Actions

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC50 value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575250 UPCDC30245 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 30 mg/mL, clear powder ≥98% (HPLC)
£571.07 (exc VAT) per 25MG
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3575251 UPCDC30245 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 30 mg/mL, clear powder ≥98% (HPLC)
£178.29 (exc VAT) per 5MG
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