UCB35625

UCB35625

Biochem/physiol Actions

UCB35625 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both UCB35625 and its enantiomer J113863 exhibit low binding affinity toward CCR2 and CCR5 where they activate three Gi and two G0 protein isoforms. UCB35625 does not activate G12 protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575646 UCB35625 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder >97% (HPLC)
£339.86 (exc VAT) per EACH
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3575647 UCB35625 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder >97% (HPLC)
£102.38 (exc VAT) per EACH
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