TREPROSTINIL

TREPROSTINIL

Biochem/physiol Actions

Treprostinil is a stable synthetic analog of prostacyclin (prostaglandin PGI2), an IP receptor agonist used clinically for the treatment of pulmonary arterial hypertension. It is a potent vasodilator with antithrombotic, antiproliferative and anti-inflammatory properties.

Treprostinil elicits a longer half-life when compared with iloprost. It mediates inhibition of transforming growth factor-? (TGF-?) and nuclear factor-?B (NF-?B) signaling pathways. Treprostinil effectively reduces right ventricular systolic pressure and inhibits the recruitment of circulating fibrocyte.

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3575040 TREPROSTINIL white to beige 100 IQKAWAUTOKVMLE-DQHZMXPSSA-M 1S/C23H34O5.Na/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25;/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27);/q;+1/p-
£1,139.36 (exc VAT) per 25MG
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3575041 TREPROSTINIL white to beige 100 IQKAWAUTOKVMLE-DQHZMXPSSA-M 1S/C23H34O5.Na/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25;/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27);/q;+1/p-
£288.32 (exc VAT) per 5MG
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