TLR4-IN-C34

TLR4-IN-C34

Application

TLR4-IN-C34 has been used as an inhibitor in the HFD-feeding mice to verify the aforementioned in vitro pathway (stearic acid/LDH-a/cytokines) in vivo.

Biochem/physiol Actions

TLR4-IN-C34 is a potent and specific inhibitor of toll-like receptor 4 (TLR4), which inhibits TLR4 signaling in vivo and in vitro. TLR4-IN-C34, also known as C34, is an aminomonosaccharide that inhibits TLR4 signaling by docking with the hydrophobic pocket of the TLR4 co-receptor, myeloid differentiation protein-2 (MD-2). C34 has been shown to diminish the severity of experimental necrotizing enterocolitis (NEC).

General description

TLR4-IN-C34 is an inhibitor of toll-like receptor 4 (TLR4) in vitro and in vivo.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574147 TLR4-IN-C34 white to beige 100 SIGMA-ALDRICH −20°C H2O: 1 mg/mL, clear (warmed) powder ≥98% (HPLC)
£552.96 (exc VAT) per 25MG
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3574148 TLR4-IN-C34 white to beige 100 SIGMA-ALDRICH −20°C H2O: 1 mg/mL, clear (warmed) powder ≥98% (HPLC)
£156.00 (exc VAT) per 5MG
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