TIC10 ANGULAR

TIC10 ANGULAR

Biochem/physiol Actions

TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers. TIC10 angular inactivates both Akt and ERK, which results in Foxo3a nuclear factor migration to the nucleus and binding to TRAIL promoter.

TIC10 (TRAIL-inducing compound 10) induces apoptosis mediated by TRAIL (TNF-related apoptosis-inducing ligand) in a number of cancers without toxicity such as breast, colon and glioblastoma multiforme tumors.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

TIC10 (TRAIL-inducing compound 10) is an anticancer molecule also referred as ONC201.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574423 TIC10 ANGULAR white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear powder ≥98% (HPLC)
£674.14 (exc VAT) per 25MG
-
+
3574424 TIC10 ANGULAR white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear powder ≥98% (HPLC)
£174.11 (exc VAT) per 5MG
-
+