TH588 HYDROCHLORIDE

TH588 HYDROCHLORIDE

Biochem/physiol Actions

TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. MTH1 hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage. MTH1 removal of oxidized nucleotides that result from increased levels of reactive oxygen species (ROS) in fast-proliferating cancer cells helps protect cancer cells from proliferative stress and prevent cancer cell death. TH588 is considered a new target for cancer therapy. TH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574465 TH588 HYDROCHLORIDE white to light brown 100 FBHMEHNWFXCSKE-UHFFFAOYSA-N 1S/C13H12Cl2N4.ClH/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10;/h1-3,6-7H,4-5H2,(H3,16,17,18,19);1H SIGMA-ALDRICH DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£728.46 (exc VAT) per 25MG
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3574466 TH588 HYDROCHLORIDE white to light brown 100 FBHMEHNWFXCSKE-UHFFFAOYSA-N 1S/C13H12Cl2N4.ClH/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10;/h1-3,6-7H,4-5H2,(H3,16,17,18,19);1H SIGMA-ALDRICH DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£203.36 (exc VAT) per 5MG
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