TAZAROTENIC ACID

TAZAROTENIC ACID

Biochem/physiol Actions

Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation.

Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) that binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575169 TAZAROTENIC ACID white to light brown 100 IQIBKLWBVJPOQO-UHFFFAOYSA-N 1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£626.79 (exc VAT) per 25MG
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3575170 TAZAROTENIC ACID white to light brown 100 IQIBKLWBVJPOQO-UHFFFAOYSA-N 1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£196.39 (exc VAT) per 5MG
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