TASIN-1 HYDROCHLORIDE

TASIN-1 HYDROCHLORIDE

Biochem/physiol Actions

TASIN-1 (Truncated APC Selective INhibitor-1) targets EBP- (Emopamil-binding protein; D8-D7 sterol isomerase) dependent cholesterol biosynthesis and selectively induces cellular cholesterol depletion and apoptotic death in human colorectal cancer (CRC) cultures harboring APC truncations under lipid-deficient conditions (0.2% FCS or 2% lipoprotein-deficient serum; IC50 from 35 nM/HT29 to 4.9 µM/HT55 in 72 hrs) as a result of defective cholesterol homeostasis regulation, while exhibiting little cytotoxicity toward wild-type APC CRC cells or non-transformed human colonic and bronchial epithelial cells (IC50 >50 µM in 72 hrs). TASIN-1 intraperitoneal injection is efficacious against the growth of CRC tumors with trunctated APC using the genetically engineered CPC;Apc mice (20 mg/kg twice a week) and two xenograft murine models (DLD1 & HT29; 40 mg/kg twice daily) without apparent toxicity to the animals.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575661 TASIN-1 HYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear
£461.04 (exc VAT) per 25MG
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3575662 TASIN-1 HYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear
£142.07 (exc VAT) per 5MG
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