SW063058

SW063058

Biochem/physiol Actions

SW063058 is an autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding, versus Bax/Bcl-2 binding. SW063058 acts by disrupting the binding of Bcl-2, a negative regulator of autophagy, to the BH3 domain of Beclin 1, which is involved in autophagy initiation. It does not inhibit Bcl-2 binding to the BH3 domain of the pro-apoptotic Bcl-2 family members BAX and BIM. In vitro experiments showed that SW063058 was not cytotoxic and induced autophagy without inducing apoptosis or other forms of cell death.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576441 SW063058 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£607.29 (exc VAT) per 25MG
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3576442 SW063058 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£151.82 (exc VAT) per 5MG
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