STF-31

STF-31

Application

STF-31 has been used in glucose transporter 1 (GLUT1) inhibition.

Biochem/physiol Actions

STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.

Features and Benefits

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Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574484 STF-31 white to beige 100 NGQPRVWTFNBUHA-UHFFFAOYSA-N 1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£594.75 (exc VAT) per 25MG
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3574485 STF-31 white to beige 100 NGQPRVWTFNBUHA-UHFFFAOYSA-N 1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£185.25 (exc VAT) per 5MG
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