ST034307

ST034307

Biochem/physiol Actions

ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575832 ST034307 faint green to dark gray SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear (warmed)
£429.00 (exc VAT) per 25MG
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3575833 ST034307 faint green to dark gray SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear (warmed)
£106.00 (exc VAT) per 5MG
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