SR2595

SR2595

Biochem/physiol Actions

SR2595 is an inverse agonist of PPARG (PPARγ) with an IC50 value of 30 nM. It was found to promote osteogenic differentiation of isolated bone marrow-derived mesenchymal stem cells accompanied by increased expression of bone morphogenetic proteins BMP2 and BMP6. SR2595 showed good pharmacokinetics and can be administered orally. It caused no significant change in insulin sensitivity, fasting insulin levels, food consumption or body weight when administered orally to mice.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575730 SR2595 white to faint brown SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£717.32 (exc VAT) per 25MG
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3575731 SR2595 white to faint brown SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£242.36 (exc VAT) per 5MG
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