SR2211

SR2211

Biochem/physiol Actions

SR2211 (ML310) is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORγ). RORγ is essential for interleukin 17 expression and differentiation of TH17 cells, important in autoimmune diseases including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and lupus. SR2211 (ML310) treatment of EL-4 murine T lymphocyte cells resulted in suppression of gene expression and production of IL-17 with an IC50 ~320 nM with no effect on the transcriptional activity of RORγ. In a mouse model of rheumatoid arthritis, SR2211 significantly reduced joint inflammation, suppressing inflammatory T cell function, expression and production of inflammatory cytokines, and macrophage activation.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574559 SR2211 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£539.04 (exc VAT) per 25MG
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3574560 SR2211 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£214.50 (exc VAT) per 5MG
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