SQ109

SQ109

Application

SQ109 has been used: as an antitubercularagent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis(Mtb) using the resazurin microtiter assay (REMA) plate method as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action

Biochem/physiol Actions

SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.

SQ109 is an antitubercular developed for the treatment of multidrug-resistant tuberculosis (MDR-TB). SQ109 inhibits the activity of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.

General description

SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.

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Code Description Colour Quality Level InChI key InChI Manufacturer Storage Temp. Form Assay Price Quantity
3574732 SQ109 colorless to yellow 100 JFIBVDBTCDTBRH-REZTVBANSA-N 1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ SIGMA-ALDRICH 2-8°C oil ≥98% (HPLC)
£408.11 (exc VAT) per 10MG
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3574733 SQ109 colorless to yellow 100 JFIBVDBTCDTBRH-REZTVBANSA-N 1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+ SIGMA-ALDRICH 2-8°C oil ≥98% (HPLC)
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