SPL-334

SPL-334

Biochem/physiol Actions

SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575498 SPL-334 white to beige 100 SIGMA-ALDRICH 2-8°C
£490.29 (exc VAT) per 25MG
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3575499 SPL-334 white to beige 100 SIGMA-ALDRICH 2-8°C
£121.32 (exc VAT) per 5MG
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