SPARSTOLONIN B

SPARSTOLONIN B

Biochem/physiol Actions

Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.

Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.

Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575356 SPARSTOLONIN B white to beige 100 SIGMA-ALDRICH 2-8°C
£536.25 (exc VAT) per 25MG
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3575357 SPARSTOLONIN B white to beige 100 SIGMA-ALDRICH 2-8°C
£131.76 (exc VAT) per 5MG
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