SID 3712249

SID 3712249

Biochem/physiol Actions

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

Other Notes

light sensitive

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575019 SID 3712249 white to brown 100 SSWVPYMSHHEYAB-UHFFFAOYSA-N 1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22) SIGMA-ALDRICH DMSO: 15 mg/mL, clear powder ≥95% (HPLC)
£373.29 (exc VAT) per 25MG
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3575020 SID 3712249 white to brown 100 SSWVPYMSHHEYAB-UHFFFAOYSA-N 1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22) SIGMA-ALDRICH DMSO: 15 mg/mL, clear powder ≥95% (HPLC)
£124.94 (exc VAT) per 5MG
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