SGC707

SGC707

Biochem/physiol Actions

SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC50 value below 1 µM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574641 SGC707 white to light brown 100 DMIDPTCQPIJYFE-UHFFFAOYSA-N 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£415.07 (exc VAT) per 25MG
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3574642 SGC707 white to light brown 100 DMIDPTCQPIJYFE-UHFFFAOYSA-N 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£128.28 (exc VAT) per 5MG
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