SB269652

SB269652

Biochem/physiol Actions

SB269652 is an allosteric modulator of D2 dopamine receptors. SB269652 binds to an allosteric site that is distinct from the orthosteric bound by typical D2 antagonists and is only revealed in D2 receptor dimers. SB269652 is bitopic, binding to an orthosteric site one one partner in the dimer and the allosteric site in the other. Engagement of this secondary pocket at the extracellular end of TM2 and TM7 is a new mechanism of modulating binding of a ligand to the orthosteric site of a second protomer by a G-protein coupled receptor.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574717 SB269652 white to beige 100 SIGMA-ALDRICH 2-8°C
£488.89 (exc VAT) per 25MG
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3574718 SB269652 white to beige 100 SIGMA-ALDRICH 2-8°C
£143.46 (exc VAT) per 5MG
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