SAG Dihydrochloride

SAG Dihydrochloride

Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:to study its effects on mouse hippocampal cellsto determine its effects on the mitochondrial network in zebrafish embryoto study its effects on murine embryonic fibroblasts

Biochem/physiol Actions

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

Packaging

1, 5 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574741 SAG Dihydrochloride white to beige 100 VFSUUTYAEQOIMW-YHBQERECSA-N 1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3 SIGMA-ALDRICH &minus;20&deg;C H<SUB>2</SUB>O: 20 mg/mL, clear lyophilized solid &ge;98% (HPLC)
£151.82 (exc VAT) per 1MG
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3574742 SAG DIHYDROCHLORIDE white to beige 100 VFSUUTYAEQOIMW-YHBQERECSA-N 1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3 SIGMA-ALDRICH &minus;20&deg;C H<SUB>2</SUB>O: 20 mg/mL, clear lyophilized solid &ge;98% (HPLC)
£591.96 (exc VAT) per 5MG
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