S3226

S3226

Biochem/physiol Actions

S3226 is a potent and selective NHE3 (NHE-3) inhibitor (IC50 = 20 nM/human NHE3, 3.6 µM/human NHE1, 80 µM/rabbit NHE2) for studying NHE3 physiological as well as pathophysiological roles in kidney and gastrointestinal disorders in vitro and in animal models in vivo.

S3226 is also known as {3-[2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methyl-phenyl]-N-isopropylidene-2-methyl-acrylamide dihydro-chloride}. S3226 is used to explore the physiological and pathophysiological functions of sodium-hydrogen exchanger 3 (NHE3) in animal models. It is a bismethacryloyl guanidine derivative.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575673 S3226 white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear
£519.54 (exc VAT) per 25MG
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3575674 S3226 white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear
£178.29 (exc VAT) per 5MG
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