S1QEL1.1

S1QEL1.1

Application

S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor: to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection in combination with mito-antioxidant to study their influence on mitochondria-derived H2O2 in cancer cells to determine the effect of oxidative stress depletion on myoblast differentiation

Biochem/physiol Actions

Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H2O2 production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H2O2 production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575600 S1QEL1.1 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£551.57 (exc VAT) per 25MG
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3575601 S1QEL1.1 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£168.54 (exc VAT) per 5MG
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