S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HP

S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HP

Application

S-(5?-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

Caution

This material is unstable at room temperature.

General description

S-(5?-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease.

Packaging

25, 100, 500 mg in poly bottle

No detailed specifications are available for this product.

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Code Description Colour Quality Level InChI key InChI Manufacturer Composition Form Assay Price Quantity
3589474 S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HP white to off-white 200 VHPOFDUCFKOUHV-XKGORWRGSA-N 1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2, SIGMA-ALDRICH p-Toluenesulfonate content, 1.6-4.4 mol/mol powder ≥80% (spectrophotometric assay), ≥80% (HPLC)
£271.61 (exc VAT) per 100MG
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3589475 S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HP white to off-white 200 VHPOFDUCFKOUHV-XKGORWRGSA-N 1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2, SIGMA-ALDRICH p-Toluenesulfonate content, 1.6-4.4 mol/mol powder ≥80% (spectrophotometric assay), ≥80% (HPLC)
£105.30 (exc VAT) per 25MG
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3589476 S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HP white to off-white 200 VHPOFDUCFKOUHV-XKGORWRGSA-N 1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2, SIGMA-ALDRICH p-Toluenesulfonate content, 1.6-4.4 mol/mol powder ≥80% (spectrophotometric assay), ≥80% (HPLC)
£1,071.11 (exc VAT) per 500MG
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