RU.521

RU.521

Biochem/physiol Actions

RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that suppresses the chronically elevated levels of type I interferon in primary macrophages from Trex1 null mice. Ru.521 binds to the CGAS catalytic pocket and inhibits dsDNA-induced cGAS-mediated interferon upregulation.

RU.521 helps to understand the biological functions of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) synthase. It can act as a molecular scaffold for developing future autoimmune therapies. RU.521 can also inhibit the inflammatory cytokine expression induced by Aspergillus fumigatus.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576178 RU.521 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£786.96 (exc VAT) per 25MG
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3576179 RU.521 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£196.39 (exc VAT) per 5MG
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