RSM932A

RSM932A

Biochem/physiol Actions

RSM932A is a potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells via prolonged activation of ER stress response and C/EBP homologous protein (CHOP) overproduction. RSM932A decreases de novo in phosphatidylcholine synthesis and increases ceramides levels that selectively trigger apoptosis in cancer cells. On the other hand, RSM932A induces reversible G0/G1 cell cycle arrest in nontumorigenic cells. RSM932A exhibits potent antiproliferative activity in array of human cancer cell lines.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576703 RSM932A faint yellow to dark orange SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear powder ≥97% (HPLC)
£487.50 (exc VAT) per EACH
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3576704 RSM932A faint yellow to dark orange SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear powder ≥97% (HPLC)
£120.34 (exc VAT) per EACH
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