ROFLUPRAM

ROFLUPRAM

Biochem/physiol Actions

Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial cells by enhancing autophagy. In microglial BV-2 cells roflupram enhanced the level of microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased the autophagy receptor ubiquitin-binding protein p62 (SQSTM1), enhancing autophagy, reducing the activation of inflammasome and suppressing the production of IL-1β. Roflupram (FFPM) was found to reverse learning and memory deficits in APP/PS1 transgenic mice.

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Code Description Colour Manufacturer Storage Temp. Form Assay Price Quantity
3575828 ROFLUPRAM colorless to light brown SIGMA-ALDRICH 2-8°C oil
£461.04 (exc VAT) per 25MG
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3575829 ROFLUPRAM colorless to light brown SIGMA-ALDRICH 2-8°C oil
£113.52 (exc VAT) per 5MG
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