RN-9893

RN-9893

Biochem/physiol Actions

RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC50 values of 420 nM, 660 nM, and 320 nM for human, rat and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 µM, an IC50 >30 µM against TRPV3, an IC50 of approximately 30 µM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.

General description

RN-9893 is a small, orally bioavailable antagonist of TRPV4 (transient receptor potential subfamily V4. It is a tri-substituted benzamide compound.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575065 RN-9893 white to beige 100 KORKKQLDGMHNKO-UHFFFAOYSA-N 1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
£388.61 (exc VAT) per 25MG
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3575066 RN-9893 white to beige 100 KORKKQLDGMHNKO-UHFFFAOYSA-N 1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
£124.94 (exc VAT) per 5MG
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