RINVANIL

RINVANIL

Biochem/physiol Actions

TRPV1 (transient receptor potential vanilloid 1) is a capsaicin receptor. It is strongly expressed in sensory neurons and participates in pain perception. In brain, it regulates neuronal function, motor behaviour and neuroinflammation. Capsaicin plays an important role in the activation of TRPV1.

Rinvanil is a Capsaicin analogue that potently activates transient receptor potential vanilloid 1 (TRPV1) channels. Rinvanil induces neuroprotective mild hypothermia in ischemic brain injured mice through TRPV1 activation. Rinvanil exhibits potent anticancer activity in cancer cell lines including cervical (HeLa, CaSKi, ViBo) and leukemia (P388, J774, WEHI-3) cell lines. Rinvanil is not cytotoxic to normal lymphocytes.

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Code Description Colour Quality Level Manufacturer Storage Temp. Form Assay Price Quantity
3575135 RINVANIL colorless to yellow 100 SIGMA-ALDRICH 2-8°C
£452.68 (exc VAT) per 25MG
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3575136 RINVANIL colorless to yellow 100 SIGMA-ALDRICH 2-8°C
£124.94 (exc VAT) per 5MG
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