RI(DL)-2

RI(DL)-2

Biochem/physiol Actions

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 µM) without affecting its ssDNA-binding activity (IC50 >100 µM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 µM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575455 RI(DL)-2 , light orange to dark red 100 SIGMA-ALDRICH 2-8°C
£435.96 (exc VAT) per 25MG
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3575456 RI(DL)-2 , light orange to dark red 100 SIGMA-ALDRICH 2-8°C
£121.32 (exc VAT) per 5MG
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