RIBOCIL-C

Biochem/physiol Actions

Ribocil-C is a potent inhibitor of bacterial riboflavin riboswitches. Riboswitches are cis regulatory elements present in non-coding RNA that specifically bind to natural ligands to regulate gene expression. Ribocil-C blocks the flavin mononucleotide riboswitch-mediated expression of the ribB gene, which is required for riboflavin biosynthesis, with an IC50 value of 23 nM. Ribocil-C inhibited bacterial cell growth of E. coli MB5746 and bacterial burden in a mouse E. coli septicaemia model of infection.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575264 RIBOCIL-C white to beige 100 SIGMA-ALDRICH 2-8°C
£626.79 (exc VAT) per 25MG
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3575265 RIBOCIL-C white to beige 100 SIGMA-ALDRICH 2-8°C
£178.29 (exc VAT) per 5MG
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