REPARIXIN

REPARIXIN

Biochem/physiol Actions

Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for CXCR1 and 100 nM for CXCR2. It is believed to prevent receptor signaling by locking CXCR1/R2 in an inactive conformation. Reparixin has been studied to prevent ischaemia-reperfusion injury and inflammation and is clinical trials for triple negative breast cancer and to prevent injury occurring after pancreatic islet transplantation.

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Code Description Colour InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576646 REPARIXIN white to beige KQDRVXQXKZXMHP-UHFFFAOYSA-N 1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16) SIGMA-ALDRICH
£690.86 (exc VAT) per EACH
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3576647 REPARIXIN white to beige KQDRVXQXKZXMHP-UHFFFAOYSA-N 1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16) SIGMA-ALDRICH
£171.32 (exc VAT) per EACH
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